RTI-111, also known as Dichloropane, is a synthetic phenyltropane research compound originally developed for investigations into monoamine transporter pharmacology. Due to its well-characterized molecular structure and activity at dopamine, norepinephrine, and serotonin transporters, RTI-111 has become an important analytical reference standard in medicinal chemistry, neuropharmacology, forensic toxicology, and analytical laboratories.
Its unique structural characteristics and relevance in neurotransmitter transporter research make RTI-111 valuable for analytical method development, structure–activity relationship (SAR) studies, drug metabolism investigations, and pharmaceutical research.
RTI-111 is supplied strictly for laboratory, analytical, and scientific research purposes only. It is not approved for human or veterinary use.
What is RTI-111 (Dichloropane)?
RTI-111 is a synthetic phenyltropane derivative belonging to the monoamine transporter inhibitor class. It is structurally related to cocaine analogs but was developed primarily as a research compound for studying dopamine, norepinephrine, and serotonin transporter interactions.
Research laboratories utilize RTI-111 as a certified analytical reference material to support transporter research, analytical method validation, forensic screening, metabolite identification, and structure–activity relationship (SAR) investigations.
Chemical Structure and Properties
RTI-111 possesses several analytical characteristics valuable for laboratory research:
- Phenyltropane core structure
- Dichlorophenyl substituted molecular framework
- High analytical stability
- Well-defined chromatographic behavior
- Excellent compatibility with LC-MS/MS and GC-MS instrumentation
- Suitable for analytical reference library development
- Reliable forensic identification marker
These characteristics enable reproducible laboratory analyses and high-confidence analytical identification.
Scientific Research Applications
RTI-111 is widely employed in:
- Analytical chemistry
- Medicinal chemistry
- Neuropharmacology research
- Drug metabolism investigations
- Forensic toxicology
- Toxicological screening
- Pharmaceutical analytical research
- Academic research
- Monoamine transporter research
- Structure–activity relationship (SAR) studies
Analytical Applications
Professional laboratories commonly use RTI-111 for:
- LC-MS/MS calibration
- GC-MS identification
- LC-HRMS analysis
- HPLC method validation
- Analytical method development
- Forensic drug screening
- Quality assurance testing
- Metabolite profiling
- Toxicology reference library creation
Its consistent analytical performance makes it valuable for modern forensic and pharmaceutical laboratories.
Pharmacology Research
Researchers investigate RTI-111 in studies involving:
- Dopamine transporter (DAT) research
- Norepinephrine transporter (NET) research
- Serotonin transporter (SERT) research
- Monoamine transporter characterization
- Structure–activity relationship (SAR) analysis
- Drug metabolism and biotransformation
- Medicinal chemistry
- Analytical toxicology
These investigations contribute to advancements in analytical science and pharmaceutical research.
Why Researchers Choose RTI-111
Researchers select RTI-111 because it provides:
- High analytical purity
- Well-characterized molecular structure
- Stable chromatographic behavior
- Excellent mass spectrometric response
- Significant pharmacological research value
- Reliable analytical reference capabilities
- Broad applicability in neuroscience and toxicology laboratories
Related Research Compounds
Researchers frequently compare RTI-111 with related compounds including:
- Cocaine
- Tesofensine
- Brasofensine
- NS-2359
- 3,4-DCMP
- O-2390
- RTI-31
- RTI-55
- WIN 35,428
- Methylecgonidine
Comparative studies support analytical identification, transporter research, metabolism studies, and structure–activity relationship investigations.
Storage and Handling
For optimal laboratory stability:
- Store in airtight laboratory containers.
- Protect from heat, moisture, and direct sunlight.
- Maintain storage in a cool, dry environment.
- Handle using appropriate laboratory personal protective equipment (PPE).
- Follow institutional laboratory safety procedures.
Frequently Asked Questions
What is RTI-111?
RTI-111 (Dichloropane) is a synthetic phenyltropane research compound used as an analytical reference standard in neuropharmacology, forensic toxicology, medicinal chemistry, and analytical chemistry.
Which laboratories use RTI-111?
It is commonly used by forensic laboratories, toxicology laboratories, neuroscience researchers, pharmaceutical researchers, academic institutions, and analytical chemistry laboratories.
Which analytical techniques are commonly used?
Researchers commonly analyze RTI-111 using LC-MS/MS, GC-MS, LC-HRMS, HPLC, and related analytical techniques.
Why is RTI-111 valuable in research?
Its well-characterized molecular profile, transporter research significance, analytical stability, and forensic relevance make it valuable for method validation, metabolite identification, transporter studies, and analytical reference development.
Is RTI-111 intended only for research?
Yes. RTI-111 is supplied exclusively for laboratory, analytical, scientific, and educational research purposes.
Disclaimer
RTI-111 is supplied strictly for laboratory, analytical, scientific, and educational research purposes only. It is not intended for human consumption, medical treatment, veterinary applications, therapeutic use, or diagnostic procedures. Users are responsible for complying with all applicable local laws, institutional policies, and laboratory safety regulations.
