U-62066, commonly known as Spiradoline, is a synthetic opioid compound belonging to the arylacetamide class and is recognized as a highly selective κ-opioid receptor (KOR) agonist. Originally developed during pharmaceutical research for its analgesic properties, it has become an important analytical reference standard used in neuropharmacology, medicinal chemistry, and forensic toxicology research.
Due to its well-characterized molecular structure and selective receptor activity, U-62066 is widely utilized in opioid receptor studies, analytical method development, medicinal chemistry, and pharmaceutical research.
U-62066 (Spiradoline) is supplied strictly for laboratory, analytical, and scientific research purposes only. It is not approved for human or veterinary use.
What is U-62066 (Spiradoline)?
U-62066 is a synthetic arylacetamide opioid developed to selectively activate κ-opioid receptors. Its high receptor selectivity has made it a valuable research compound for investigating opioid receptor pharmacology, receptor signaling, analgesic mechanisms, and structure–activity relationships.
Research laboratories utilize U-62066 as a certified analytical reference material for analytical method validation, receptor research, forensic identification, metabolite investigations, and pharmaceutical analytical studies.
Chemical Structure and Properties
U-62066 possesses several analytical characteristics valuable for laboratory research:
- Arylacetamide opioid structure
- Highly selective κ-opioid receptor agonist
- Well-characterized molecular profile
- High analytical stability
- Excellent chromatographic behavior
- Strong compatibility with LC-MS/MS and GC-MS instrumentation
- Suitable for analytical reference library development
- Reliable forensic identification marker
These characteristics enable reproducible laboratory analyses and accurate compound identification.
Scientific Research Applications
U-62066 is widely employed in:
- Analytical chemistry
- Medicinal chemistry
- Neuropharmacology research
- Opioid receptor investigations
- Pharmaceutical research
- Drug metabolism studies
- Forensic toxicology
- Toxicological screening
- Academic research
- Reference standard development
Analytical Applications
Professional laboratories commonly use U-62066 for:
- LC-MS/MS calibration
- GC-MS identification
- LC-HRMS analysis
- HPLC method validation
- Analytical method development
- Opioid receptor research
- Pharmaceutical quality assurance
- Forensic drug screening
- Toxicology reference library creation
Its reliable analytical performance makes it valuable for modern forensic and pharmaceutical laboratories.
Pharmacology Research
Researchers investigate U-62066 in studies involving:
- κ-Opioid receptor (KOR) pharmacology
- Opioid receptor signaling
- Structure–activity relationship (SAR) analysis
- Drug metabolism and biotransformation
- Neuropharmacology
- Medicinal chemistry
- Analytical toxicology
- Receptor binding studies
These investigations contribute to advancements in analytical science, neuroscience, and pharmaceutical research.
Why Researchers Choose U-62066
Researchers select U-62066 because it provides:
- High analytical purity
- Well-characterized molecular structure
- Stable chromatographic behavior
- Excellent mass spectrometric response
- Highly selective κ-opioid receptor activity
- Reliable analytical reference capabilities
- Broad applicability in neuropharmacology laboratories
Related Research Compounds
Researchers frequently compare U-62066 with related compounds including:
- U-50488
- U-48800
- U-47700
- Enadoline
- Ketazocine
- Alazocine
- Butorphanol
- Pentazocine
- Isotonitazene
- Metonitazene
Comparative studies support analytical identification, opioid receptor research, and structure–activity relationship investigations.
Storage and Handling
For optimal laboratory stability:
- Store in airtight laboratory containers.
- Protect from heat, moisture, and direct sunlight.
- Maintain storage in a cool, dry environment.
- Handle using appropriate laboratory personal protective equipment (PPE).
- Follow institutional laboratory safety procedures.
Frequently Asked Questions
What is U-62066 (Spiradoline)?
U-62066 (Spiradoline) is a synthetic κ-opioid receptor agonist used as an analytical reference standard in neuropharmacology, medicinal chemistry, forensic toxicology, and analytical chemistry research.
Which laboratories use U-62066?
It is commonly used by neuroscience laboratories, pharmaceutical researchers, forensic laboratories, toxicology laboratories, academic institutions, and analytical chemistry laboratories.
Which analytical techniques are commonly used?
Researchers commonly analyze U-62066 using LC-MS/MS, GC-MS, LC-HRMS, HPLC, and related analytical techniques.
Why is U-62066 valuable in research?
Its well-characterized molecular profile, high receptor selectivity, and analytical stability make it valuable for receptor pharmacology, analytical method validation, metabolite identification, and analytical reference development.
Is U-62066 intended only for research?
Yes. U-62066 is supplied exclusively for laboratory, analytical, scientific, and educational research purposes.
Disclaimer
U-62066 (Spiradoline) is supplied strictly for laboratory, analytical, scientific, and educational research purposes only. It is not intended for human consumption, medical treatment, veterinary applications, therapeutic use, or diagnostic procedures. Users are responsible for complying with all applicable local laws, institutional policies, and laboratory safety regulations.
