CRL-40,941, comúnmente conocido como Fladrafinil o Bisfluoroadrafiniles una de alta pureza eugeroic (wakefulness-promoting) research chemical belonging to the diphenylmethyl sulfinyl acetamide family. Developed by Laboratoire Lafon during investigations into next-generation wakefulness-promoting compounds, Fladrafinil is a fluorinated analogue of Adrafinil and is closely related to Modafinil and Flmodafinil (CRL-40,940).

Although never approved as a pharmaceutical medication, CRL-40,941 has become an important analytical reference material for laboratories studying wakefulness-promoting agents, dopamine transporter pharmacology, medicinal chemistry, metabolism, and neuropharmacology.

What is CRL-40,941 (Fladrafinil)?

Fladrafinil is a fluorinated derivative of Adrafinil developed during research into compounds that promote wakefulness and cognitive function. Structurally, it differs from Adrafinil by the addition of fluorine atoms on both aromatic rings, a modification used in medicinal chemistry to investigate how halogen substitution affects pharmacological properties, metabolic stability, and receptor interactions.

Because of its defined chemical profile, CRL-40,941 is widely used as a reference standard in analytical laboratories and pharmaceutical research.

Estructura y Propiedades químicas

CRL-40,941 contains several notable structural features:

• Diphenylmethyl sulfoxide core
• Hydroxamic acid functionality
• Two para-fluorophenyl rings
• Sulfinyl linkage
• Alta estabilidad química
• Polvo cristalino de grado de laboratorio

These characteristics make it useful for chromatographic analysis, analytical validation, and medicinal chemistry investigations.

La Investigación Farmacológica

Scientific literature indicates that Fladrafinil belongs to the same pharmacological family as Modafinil and Adrafinil. Research suggests that compounds within this family influence dopamine transporter (DAT) activity, making them valuable tools for studying wakefulness mechanisms and central nervous system pharmacology.

Current research areas include:

• Dopamine transporter (DAT) investigations
• Wakefulness-promoting compound research
• Neurochemical signaling
• Cognitive enhancer pharmacology
• Comparative studies with Modafinil analogues
• Relación estructura–actividad (SAR), el análisis
• Drug metabolism and pharmacokinetics

Animal studies have also explored behavioral effects, including wakefulness and anti-aggressive activity, although further research is needed to fully characterize its pharmacological profile.

Las Aplicaciones De La Investigación Científica

CRL-40,941 is frequently used in:

• Desarrollo farmacéutico
• Laboratorios de química medicinal
• Investigación en neurofarmacología
• Académico de la neurociencia
• química analítica
• Metabolismo de los fármacos investigaciones
• Toxicología forense
• Estándar de referencia de la producción
• Laboratorios de control de calidad

Aplicaciones Analíticas

Researchers utilize Fladrafinil for:

• LC-MS/MS method development
• GC-MS analytical calibration
• HPLC analysis
• Espectrometría de masas de alta resolución (HRMS)
• Creación de bibliotecas de referencia
• La validación del método
• Identificación compuesta
• Stability testing
• Quality assurance protocols

Its well-defined analytical profile supports accurate differentiation from related compounds such as Modafinil, Adrafinil, and Flmodafinil.

Why Researchers Choose CRL-40,941

Researchers value Fladrafinil because it offers:

• Bien caracterizada la estructura molecular
• De alta pureza analítica
• Comportamiento cromatográfico fiable
• Excelente reproducibilidad analítica
• Useful SAR comparison with Modafinil analogues
• Broad application in neuropharmacology
• Rendimiento de laboratorio constante

La Investigación Relacionada Con Los Compuestos

Fladrafinil is commonly studied alongside:

• Modafinil
• Armodafinil
• Adrafinil
• Flmodafinil (CRL-40,940)
• CE-123
• Modafinil analogues
• Eugeroic research compounds

Comparative investigations help researchers understand transporter interactions, metabolism, and structural modifications within the eugeroic class.

El almacenamiento y la Manipulación

Para una óptima laboratorio de estabilidad:

• Tienda en herméticos recipientes de laboratorio.
• Proteger de la humedad.
• Keep away from direct sunlight.
• Mantener recomendados laboratorio de temperaturas de almacenamiento.
• Manipular utilizando el equipo de protección individual (EPI) de laboratorio adecuado.
• Siga institucional de laboratorio, procedimientos de seguridad.

Preguntas frecuentes

What is CRL-40,941?

CRL-40,941 (Fladrafinil) is a fluorinated analogue of Adrafinil used as an analytical reference standard in neuropharmacology, medicinal chemistry, pharmaceutical research, and forensic toxicology.

Which laboratories use Fladrafinil?

It is commonly used by pharmaceutical companies, forensic laboratories, academic institutions, medicinal chemists, and analytical chemistry laboratories.

Which analytical techniques are suitable for CRL-40,941?

Researchers commonly analyze Fladrafinil using LC-MS/MS, GC-MS, HPLC, and HRMS for calibration, compound identification, and analytical method validation.

Why is Fladrafinil valuable for research?

Its defined molecular structure, relationship to Modafinil analogues, and analytical consistency make it useful for pharmacological research, transporter studies, and medicinal chemistry investigations.

Is CRL-40,941 intended only for research?

Sí. Este producto se suministra exclusivamente para laboratorio, analíticos, científicos, educativos y de los propósitos de la investigación.

Descargo de responsabilidad

CRL-40,941 (Fladrafinil) se suministra Estrictamente para fines de investigación de laboratorio, analítica, científica y educativa únicamente.. Es not intended for human consumption, therapeutic use, veterinary applications, medical treatment, or diagnostic purposes. Researchers are responsible for complying with all applicable laws, institutional policies, and laboratory safety regulations.