{"id":34409,"date":"2026-09-28T21:11:24","date_gmt":"2026-09-28T21:11:24","guid":{"rendered":"https:\/\/izchem.com\/?post_type=product&p=34409"},"modified":"2026-09-28T21:11:31","modified_gmt":"2026-09-28T21:11:31","slug":"crl-40941","status":"publish","type":"product","link":"https:\/\/izchem.com\/fr\/crl-40941\/","title":{"rendered":"CRL-40,941"},"content":{"rendered":"

CRL-40,941<\/strong>, commun\u00e9ment appel\u00e9 Fladrafinil<\/strong> ou Bisfluoroadrafinil<\/strong>, est d'une grande puret\u00e9 eugeroic (wakefulness-promoting) research chemical<\/strong> belonging to the diphenylmethyl sulfinyl acetamide family. Developed by Laboratoire Lafon during investigations into next-generation wakefulness-promoting compounds, Fladrafinil is a fluorinated analogue of Adrafinil<\/strong> and is closely related to Modafinil<\/strong> et Flmodafinil (CRL-40,940)<\/strong>.<\/p>\n

Although never approved as a pharmaceutical medication, CRL-40,941 has become an important analytical reference material for laboratories studying wakefulness-promoting agents, dopamine transporter pharmacology, medicinal chemistry, metabolism, and neuropharmacology.<\/p>\n

What is CRL-40,941 (Fladrafinil)?<\/h1>\n

Fladrafinil is a fluorinated derivative of Adrafinil developed during research into compounds that promote wakefulness and cognitive function. Structurally, it differs from Adrafinil by the addition of fluorine atoms on both aromatic rings, a modification used in medicinal chemistry to investigate how halogen substitution affects pharmacological properties, metabolic stability, and receptor interactions.<\/p>\n

Because of its defined chemical profile, CRL-40,941 is widely used as a reference standard in analytical laboratories and pharmaceutical research.<\/p>\n

La Structure chimique et les Propri\u00e9t\u00e9s<\/h1>\n

CRL-40,941 contains several notable structural features:<\/p>\n

    \n
  • Diphenylmethyl sulfoxide core<\/li>\n
  • Hydroxamic acid functionality<\/li>\n
  • Two para-fluorophenyl rings<\/li>\n
  • Sulfinyl linkage<\/li>\n
  • Haute stabilit\u00e9 chimique<\/li>\n
  • Poudre de qualit\u00e9 laboratoire cristalline<\/li>\n<\/ul>\n

    These characteristics make it useful for chromatographic analysis, analytical validation, and medicinal chemistry investigations.<\/p>\n

    La Recherche Pharmacologique<\/h1>\n

    Scientific literature indicates that Fladrafinil belongs to the same pharmacological family as Modafinil and Adrafinil. Research suggests that compounds within this family influence Transporteur de dopamine (DAT)<\/strong> activity, making them valuable tools for studying wakefulness mechanisms and central nervous system pharmacology.<\/p>\n

    Current research areas include:<\/p>\n

      \n
    • Dopamine transporter (DAT) investigations<\/li>\n
    • Wakefulness-promoting compound research<\/li>\n
    • Neurochemical signaling<\/li>\n
    • Cognitive enhancer pharmacology<\/li>\n
    • Comparative studies with Modafinil analogues<\/li>\n
    • Relation Structure\u2013activit\u00e9 (SAR) analyse<\/li>\n
    • Drug metabolism and pharmacokinetics<\/li>\n<\/ul>\n

      Animal studies have also explored behavioral effects, including wakefulness and anti-aggressive activity, although further research is needed to fully characterize its pharmacological profile.<\/p>\n

      Les Applications Scientifiques<\/h1>\n

      CRL-40,941 is frequently used in:<\/p>\n

        \n
      • d\u00e9veloppement pharmaceutique<\/li>\n
      • Laboratoires de chimie m\u00e9dicinale<\/li>\n
      • Recherche en neuropharmacologie<\/li>\n
      • Universitaire en neurosciences<\/li>\n
      • Chimie analytique<\/li>\n
      • Le m\u00e9tabolisme des m\u00e9dicaments enqu\u00eates<\/li>\n
      • Toxicologie m\u00e9dico-l\u00e9gale<\/li>\n
      • Norme de r\u00e9f\u00e9rence de la production<\/li>\n
      • Laboratoire de contr\u00f4le de qualit\u00e9<\/li>\n<\/ul>\n

        Applications Analytiques De<\/h1>\n

        Researchers utilize Fladrafinil for:<\/p>\n

          \n
        • LC-MS\/MS method development<\/li>\n
        • GC-MS analytical calibration<\/li>\n
        • analyse HPLC<\/li>\n
        • Spectrom\u00e9trie de masse \u00e0 haute r\u00e9solution (HRMS)<\/li>\n
        • Cr\u00e9ation d'une biblioth\u00e8que de r\u00e9f\u00e9rence<\/li>\n
        • Validation de la m\u00e9thode<\/li>\n
        • Identification du compos\u00e9<\/li>\n
        • Stability testing<\/li>\n
        • Quality assurance protocols<\/li>\n<\/ul>\n

          Its well-defined analytical profile supports accurate differentiation from related compounds such as Modafinil, Adrafinil, and Flmodafinil.<\/p>\n

          Why Researchers Choose CRL-40,941<\/h1>\n

          Researchers value Fladrafinil because it offers:<\/p>\n

            \n
          • Bien caract\u00e9ris\u00e9 la structure mol\u00e9culaire<\/li>\n
          • Haute puret\u00e9 analytique<\/li>\n
          • Comportement chromatographique fiable<\/li>\n
          • Excellente reproductibilit\u00e9 analytique<\/li>\n
          • Useful SAR comparison with Modafinil analogues<\/li>\n
          • Broad application in neuropharmacology<\/li>\n
          • Performances constantes en laboratoire<\/li>\n<\/ul>\n

            Recherche Li\u00e9e \u00c0 Des Compos\u00e9s<\/h1>\n

            Fladrafinil is commonly studied alongside:<\/p>\n

              \n
            • Modafinil<\/li>\n
            • Armodafinil<\/li>\n
            • Adrafinil<\/li>\n
            • Flmodafinil (CRL-40,940)<\/li>\n
            • CE-123<\/li>\n
            • Modafinil analogues<\/li>\n
            • Eugeroic research compounds<\/li>\n<\/ul>\n

              Comparative investigations help researchers understand transporter interactions, metabolism, and structural modifications within the eugeroic class.<\/p>\n

              De stockage et de Manutention<\/h1>\n

              Pour optimiser le laboratoire de la stabilit\u00e9:<\/p>\n

                \n
              • Magasin \u00e9tanche \u00e0 l'air dans les r\u00e9cipients de laboratoire.<\/li>\n
              • Prot\u00e9ger de l'humidit\u00e9.<\/li>\n
              • Keep away from direct sunlight.<\/li>\n
              • Maintenir recommand\u00e9 de laboratoire temp\u00e9ratures de stockage.<\/li>\n
              • Manipuler en utilisant un \u00e9quipement de protection individuelle (EPI) de laboratoire appropri\u00e9.<\/li>\n
              • Suivez laboratoire institutionnel proc\u00e9dures de s\u00e9curit\u00e9.<\/li>\n<\/ul>\n

                Foire aux questions<\/h1>\n

                What is CRL-40,941?<\/h3>\n

                CRL-40,941 (Fladrafinil) is a fluorinated analogue of Adrafinil used as an analytical reference standard in neuropharmacology, medicinal chemistry, pharmaceutical research, and forensic toxicology.<\/p>\n

                Which laboratories use Fladrafinil?<\/h3>\n

                It is commonly used by pharmaceutical companies, forensic laboratories, academic institutions, medicinal chemists, and analytical chemistry laboratories.<\/p>\n

                Which analytical techniques are suitable for CRL-40,941?<\/h3>\n

                Researchers commonly analyze Fladrafinil using LC-MS\/MS, GC-MS, HPLC, and HRMS for calibration, compound identification, and analytical method validation.<\/p>\n

                Why is Fladrafinil valuable for research?<\/h3>\n

                Its defined molecular structure, relationship to Modafinil analogues, and analytical consistency make it useful for pharmacological research, transporter studies, and medicinal chemistry investigations.<\/p>\n

                Is CRL-40,941 intended only for research?<\/h3>\n

                Oui. Ce produit est fourni exclusivement pour le laboratoire, analytique, scientifique, et de l'enseignement des fins de recherche.<\/p>\n

                Avertissement<\/h1>\n

                CRL-40,941 (Fladrafinil)<\/strong> est fourni uniquement \u00e0 des fins de recherche en laboratoire, analytiques, scientifiques et p\u00e9dagogiques<\/strong>. Il est not intended for human consumption, therapeutic use, veterinary applications, medical treatment, or diagnostic purposes<\/strong>. Researchers are responsible for complying with all applicable laws, institutional policies, and laboratory safety regulations.<\/p>","protected":false},"excerpt":{"rendered":"

                  \n
                • Nom Du Produit:<\/strong>CRL-40,941<\/li>\n
                • Noms Alternatifs: <\/strong>Fladrafinil, Fluorafinil, Bisfluoroadrafinil<\/li>\n
                • Classe Chimique: <\/strong>Diphenylmethyl Sulfinyl Acetamide<\/li>\n
                • Cat\u00e9gorie de recherche\u00a0: <\/strong>R\u00e9f\u00e9rence Analytique Standard<\/li>\n<\/ul>","protected":false},"featured_media":34429,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_uag_custom_page_level_css":"","site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center 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