Duloxetine (Cymbalta): Uses, Side Effects, Dosage & More
Duloxetine (Cymbalta) is used to treat depression, anxiety, and some forms of long-term pain. This medication is an antidepressant that’s called an SNRI or serotonin and norepinephrine reuptake inhibitor.
The dosage is typically one capsule by mouth once daily (or twice daily for some people with depression). Side effects can include nausea, headache, and dry mouth. If you need to stop the medication for any reason, your prescriber will lower your dose slowly over time to prevent withdrawal symptoms like anxiety and trouble sleeping.
What is Duloxetine (Cymbalta) used for?
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Major depressive disorder in adults
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Generalized anxiety disorder in people age 7 years and older
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Diabetic neuropathy (nerve pain caused by high blood sugar) in adults
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Fibromyalgia in people age 13 years and older
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Long-term pain in the muscles, bones, joints, or tendons in adults
How Duloxetine (Cymbalta) works
duloxetine gastro-resistant tablet (Cymbalta) is an SNRI or a serotonin and norepinephrine reuptake inhibitor. It’s thought to help improve mood and pain by raising the level of chemicals called serotonin and norepinephrine in your brain.
What are the side effects of Duloxetine (Cymbalta)?
Common Side Effects
- Nausea (23%)
- Headache (14%)
- Dry mouth (13%)
- Drowsiness (10%)
- Feeling tired (9%)
- Trouble sleeping (9%)
- Dizziness (9%)
- Constipation (9%)
- Diarrhea (9%)
- Low appetite (7%)
- A lot of sweating (6%)
- Stomach pain (5%)
Other Side Effects | Duloxetine side effects
- Blurry vision
- Abnormal heartbeat
- Tremor
- Vomiting
- Low sex drive
- Yawning
- Change in weight
Note: These side effects were reported in adults. Side effects that children might have can be different.
Serious Side Effects Duloxetine 30 mg
- Suicidal thoughts or behaviours | Duloxetine withdrawal
- Liver damage: nausea, vomiting, loss of appetite, severe stomach pain, yellowing of the skin or whites of the eyes
- Serotonin syndrome: restlessness, fast heartbeat, diarrhoea, nausea, vomiting, feeling very warm, fever, abnormal eye movements, loss of balance, muscle spasms, tremors
- Severe bleeding or bruising: bruising that doesn’t improve, black-coloured stools, pink or red-coloured urine, coughing up or vomiting blood, unusual bleeding from the nose or gums
- Low sodium levels: headaches, trouble concentrating, memory problems, weakness, confusion, hallucinations
- Severe skin reaction: blisters, peeling rash, sores, hives
- Seizure
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