{"id":34409,"date":"2026-09-28T21:11:24","date_gmt":"2026-09-28T21:11:24","guid":{"rendered":"https:\/\/izchem.com\/?post_type=product&p=34409"},"modified":"2026-09-28T21:11:31","modified_gmt":"2026-09-28T21:11:31","slug":"crl-40941","status":"publish","type":"product","link":"https:\/\/izchem.com\/pt\/crl-40941\/","title":{"rendered":"CRL-40,941"},"content":{"rendered":"

CRL-40,941<\/strong>, vulgarmente conhecido como Fladrafinil<\/strong> ou Bisfluoroadrafinil<\/strong>\u00e9 um alto grau de pureza eugeroic (wakefulness-promoting) research chemical<\/strong> belonging to the diphenylmethyl sulfinyl acetamide family. Developed by Laboratoire Lafon during investigations into next-generation wakefulness-promoting compounds, Fladrafinil is a fluorinated analogue of Adrafinil<\/strong> and is closely related to Modafinil<\/strong> e Flmodafinil (CRL-40,940)<\/strong>.<\/p>\n

Although never approved as a pharmaceutical medication, CRL-40,941 has become an important analytical reference material for laboratories studying wakefulness-promoting agents, dopamine transporter pharmacology, medicinal chemistry, metabolism, and neuropharmacology.<\/p>\n

What is CRL-40,941 (Fladrafinil)?<\/h1>\n

Fladrafinil is a fluorinated derivative of Adrafinil developed during research into compounds that promote wakefulness and cognitive function. Structurally, it differs from Adrafinil by the addition of fluorine atoms on both aromatic rings, a modification used in medicinal chemistry to investigate how halogen substitution affects pharmacological properties, metabolic stability, and receptor interactions.<\/p>\n

Because of its defined chemical profile, CRL-40,941 is widely used as a reference standard in analytical laboratories and pharmaceutical research.<\/p>\n

Estrutura qu\u00edmica e Propriedades<\/h1>\n

CRL-40,941 contains several notable structural features:<\/p>\n

    \n
  • Diphenylmethyl sulfoxide core<\/li>\n
  • Hydroxamic acid functionality<\/li>\n
  • Two para-fluorophenyl rings<\/li>\n
  • Sulfinyl linkage<\/li>\n
  • Alta estabilidade qu\u00edmica<\/li>\n
  • P\u00f3 cristalino de grau laboratorial<\/li>\n<\/ul>\n

    These characteristics make it useful for chromatographic analysis, analytical validation, and medicinal chemistry investigations.<\/p>\n

    Investiga\u00e7\u00e3o Farmacol\u00f3gica<\/h1>\n

    Scientific literature indicates that Fladrafinil belongs to the same pharmacological family as Modafinil and Adrafinil. Research suggests that compounds within this family influence dopamine transporter (DAT)<\/strong> activity, making them valuable tools for studying wakefulness mechanisms and central nervous system pharmacology.<\/p>\n

    Current research areas include:<\/p>\n

      \n
    • Dopamine transporter (DAT) investigations<\/li>\n
    • Wakefulness-promoting compound research<\/li>\n
    • Neurochemical signaling<\/li>\n
    • Cognitive enhancer pharmacology<\/li>\n
    • Comparative studies with Modafinil analogues<\/li>\n
    • Rela\u00e7\u00e3o estrutura\u2013atividade (SAR) de an\u00e1lise<\/li>\n
    • Drug metabolism and pharmacokinetics<\/li>\n<\/ul>\n

      Animal studies have also explored behavioral effects, including wakefulness and anti-aggressive activity, although further research is needed to fully characterize its pharmacological profile.<\/p>\n

      A Investiga\u00e7\u00e3o Cient\u00edfica Aplica\u00e7\u00f5es<\/h1>\n

      CRL-40,941 is frequently used in:<\/p>\n

        \n
      • Desenvolvimento farmac\u00eautico<\/li>\n
      • Laborat\u00f3rios de qu\u00edmica medicinal<\/li>\n
      • Investiga\u00e7\u00e3o em neurofarmacologia<\/li>\n
      • Acad\u00eamica de neuroci\u00eancia<\/li>\n
      • Qu\u00edmica anal\u00edtica<\/li>\n
      • Investiga\u00e7\u00f5es sobre o metabolismo dos f\u00e1rmacos<\/li>\n
      • Toxicologia forense<\/li>\n
      • Padr\u00e3o de refer\u00eancia de produ\u00e7\u00e3o<\/li>\n
      • Laborat\u00f3rios de controle de qualidade<\/li>\n<\/ul>\n

        Aplica\u00e7\u00f5es Anal\u00edticas<\/h1>\n

        Researchers utilize Fladrafinil for:<\/p>\n

          \n
        • LC-MS\/MS method development<\/li>\n
        • GC-MS analytical calibration<\/li>\n
        • An\u00e1lise por HPLC<\/li>\n
        • Espectrometria de massas de alta resolu\u00e7\u00e3o (HRMS)<\/li>\n
        • Cria\u00e7\u00e3o de biblioteca de refer\u00eancia<\/li>\n
        • Valida\u00e7\u00e3o do m\u00e9todo<\/li>\n
        • Identifica\u00e7\u00e3o do composto<\/li>\n
        • Stability testing<\/li>\n
        • Quality assurance protocols<\/li>\n<\/ul>\n

          Its well-defined analytical profile supports accurate differentiation from related compounds such as Modafinil, Adrafinil, and Flmodafinil.<\/p>\n

          Why Researchers Choose CRL-40,941<\/h1>\n

          Researchers value Fladrafinil because it offers:<\/p>\n

            \n
          • Bem-caracteriza-se a estrutura molecular<\/li>\n
          • De alta pureza anal\u00edtica<\/li>\n
          • Comportamento cromatogr\u00e1fico fi\u00e1vel<\/li>\n
          • Excelente reprodutibilidade anal\u00edtica<\/li>\n
          • Useful SAR comparison with Modafinil analogues<\/li>\n
          • Broad application in neuropharmacology<\/li>\n
          • Desempenho consistente em laborat\u00f3rio<\/li>\n<\/ul>\n

            A Investiga\u00e7\u00e3o Relacionada Com Compostos<\/h1>\n

            Fladrafinil is commonly studied alongside:<\/p>\n

              \n
            • Modafinil<\/li>\n
            • Armodafinil<\/li>\n
            • Adrafinil<\/li>\n
            • Flmodafinil (CRL-40,940)<\/li>\n
            • CE-123<\/li>\n
            • Modafinil analogues<\/li>\n
            • Eugeroic research compounds<\/li>\n<\/ul>\n

              Comparative investigations help researchers understand transporter interactions, metabolism, and structural modifications within the eugeroic class.<\/p>\n

              Armazenamento e Manipula\u00e7\u00e3o<\/h1>\n

              Para um \u00f3ptimo laborat\u00f3rio de estabilidade:<\/p>\n

                \n
              • Loja em herm\u00e9tico recipientes de laborat\u00f3rio.<\/li>\n
              • Proteger da humidade e do bolor.<\/li>\n
              • Keep away from direct sunlight.<\/li>\n
              • Manter recomendada laborat\u00f3rio de temperaturas de armazenamento.<\/li>\n
              • Manusear utilizando equipamento de prote\u00e7\u00e3o individual (EPI) de laborat\u00f3rio apropriado.<\/li>\n
              • Siga institucionais laborat\u00f3rio de procedimentos de seguran\u00e7a.<\/li>\n<\/ul>\n

                Perguntas frequentes<\/h1>\n

                What is CRL-40,941?<\/h3>\n

                CRL-40,941 (Fladrafinil) is a fluorinated analogue of Adrafinil used as an analytical reference standard in neuropharmacology, medicinal chemistry, pharmaceutical research, and forensic toxicology.<\/p>\n

                Which laboratories use Fladrafinil?<\/h3>\n

                It is commonly used by pharmaceutical companies, forensic laboratories, academic institutions, medicinal chemists, and analytical chemistry laboratories.<\/p>\n

                Which analytical techniques are suitable for CRL-40,941?<\/h3>\n

                Researchers commonly analyze Fladrafinil using LC-MS\/MS, GC-MS, HPLC, and HRMS for calibration, compound identification, and analytical method validation.<\/p>\n

                Why is Fladrafinil valuable for research?<\/h3>\n

                Its defined molecular structure, relationship to Modafinil analogues, and analytical consistency make it useful for pharmacological research, transporter studies, and medicinal chemistry investigations.<\/p>\n

                Is CRL-40,941 intended only for research?<\/h3>\n

                Sim. Este produto \u00e9 fornecido exclusivamente para a \u00e1rea laboratorial, anal\u00edtico, cient\u00edfico e educacional fins de pesquisa.<\/p>\n

                Isen\u00e7\u00e3o de responsabilidade<\/h1>\n

                CRL-40,941 (Fladrafinil)<\/strong> \u00e9 fornecido estritamente para fins de investiga\u00e7\u00e3o laboratorial, anal\u00edtica, cient\u00edfica e educacional.<\/strong>. \u00c9 not intended for human consumption, therapeutic use, veterinary applications, medical treatment, or diagnostic purposes<\/strong>. Researchers are responsible for complying with all applicable laws, institutional policies, and laboratory safety regulations.<\/p>","protected":false},"excerpt":{"rendered":"

                  \n
                • Nome Do Produto:<\/strong>CRL-40,941<\/li>\n
                • Nomes Alternativos: <\/strong>Fladrafinil, Fluorafinil, Bisfluoroadrafinil<\/li>\n
                • Classe Qu\u00edmica: <\/strong>Diphenylmethyl Sulfinyl Acetamide<\/li>\n
                • Categoria de pesquisa: <\/strong>Anal\u00edtico De Refer\u00eancia Padr\u00e3o<\/li>\n<\/ul>","protected":false},"featured_media":34429,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_uag_custom_page_level_css":"","site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center 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