U-62066, commonly known as Spiradoline, is a synthetic opioid compound belonging to the arylacetamide class and is recognized as a highly selective κ-opioid receptor (KOR) agonist. Originally developed during pharmaceutical research for its analgesic properties, it has become an important analytical reference standard used in neuropharmacology, medicinal chemistry, and forensic toxicology research.

Due to its well-characterized molecular structure and selective receptor activity, U-62066 is widely utilized in opioid receptor studies, analytical method development, medicinal chemistry, and pharmaceutical research.

U-62066 (Spiradoline) is supplied strictly for laboratory, analytical, and scientific research purposes only. It is not approved for human or veterinary use.

What is U-62066 (Spiradoline)?

U-62066 is a synthetic arylacetamide opioid developed to selectively activate κ-opioid receptors. Its high receptor selectivity has made it a valuable research compound for investigating opioid receptor pharmacology, receptor signaling, analgesic mechanisms, and structure–activity relationships.

Research laboratories utilize U-62066 as a certified analytical reference material for analytical method validation, receptor research, forensic identification, metabolite investigations, and pharmaceutical analytical studies.

Estrutura química e Propriedades

U-62066 possesses several analytical characteristics valuable for laboratory research:

• Arylacetamide opioid structure
• Highly selective κ-opioid receptor agonist
• Perfil molecular bem caracterizado
• Elevada estabilidade analítica
• Excelente comportamento cromatográfico
• Elevada compatibilidade com instrumentos LC-MS/MS e GC-MS.
• Adequado para o desenvolvimento de bibliotecas de referência analíticas.
• Marcador de identificação forense fiável

Estas características permitem análises laboratoriais reproduzíveis e identificação precisa dos compostos.

A Investigação Científica Aplicações

U-62066 is widely employed in:

• química analítica
• química medicinal
• Investigação em neurofarmacologia
• Opioid receptor investigations
• A pesquisa farmacêutica
• Metabolismo dos fármacos estudos
• toxicologia forense
• Triagem toxicológica
• Pesquisa acadêmica
• Desenvolvimento de padrão de referência

Aplicações Analíticas

Professional laboratories commonly use U-62066 for:

• LC-MS/MS de calibração
• Identificação por GC-MS
• Análise LC-HRMS
• Validação do método HPLC
• Desenvolvimento de métodos analíticos
• Investigação sobre receptores opioides
• Pharmaceutical quality assurance
• rastreio forense de drogas
• Criação de biblioteca de referência em toxicologia

O seu desempenho analítico fiável torna-o valioso para laboratórios forenses e farmacêuticos modernos.

Investigação em Farmacologia

Researchers investigate U-62066 in studies involving:

• κ-Opioid receptor (KOR) pharmacology
• Opioid receptor signaling
• Análise da relação estrutura-atividade (SAR)
• Metabolismo e biotransformação de fármacos
• Neurofarmacologia
• química medicinal
• Toxicologia analítica
• Estudos de ligação ao recetor

These investigations contribute to advancements in analytical science, neuroscience, and pharmaceutical research.

Why Researchers Choose U-62066

Researchers select U-62066 because it provides:

• De alta pureza analítica
• Bem-caracteriza-se a estrutura molecular
• Comportamento cromatográfico estável
• Excelente resposta em espectrometria de massas
• Highly selective κ-opioid receptor activity
• Capacidades de referência analítica fiáveis
• Broad applicability in neuropharmacology laboratories

A Investigação Relacionada Com Compostos

Researchers frequently compare U-62066 with related compounds including:

• U-50488
• U-48800
• U-47700
• Enadoline
• Ketazocine
• Alazocine
• Butorfanol
• Pentazocine
• Isotonitazeno
• Metonitazeno

Os estudos comparativos apoiam a identificação analítica, a pesquisa de recetores opióides e as investigações da relação estrutura-atividade.

Armazenamento e Manipulação

Para um óptimo laboratório de estabilidade:

• Loja em hermético recipientes de laboratório.
• Proteger do calor, da humidade e da luz solar direta.
• Conservar em local fresco e seco.
• Manuseie utilizando os equipamentos de proteção individual (EPI) de laboratório adequados.
• Siga institucionais laboratório de procedimentos de segurança.

Perguntas Frequentes

What is U-62066 (Spiradoline)?

U-62066 (Spiradoline) is a synthetic κ-opioid receptor agonist used as an analytical reference standard in neuropharmacology, medicinal chemistry, forensic toxicology, and analytical chemistry research.

Which laboratories use U-62066?

It is commonly used by neuroscience laboratories, pharmaceutical researchers, forensic laboratories, toxicology laboratories, academic institutions, and analytical chemistry laboratories.

Que técnicas analíticas são comummente utilizadas?

Researchers commonly analyze U-62066 using LC-MS/MS, GC-MS, LC-HRMS, HPLC, and related analytical techniques.

Why is U-62066 valuable in research?

Its well-characterized molecular profile, high receptor selectivity, and analytical stability make it valuable for receptor pharmacology, analytical method validation, metabolite identification, and analytical reference development.

Is U-62066 intended only for research?

Yes. U-62066 is supplied exclusively for laboratory, analytical, scientific, and educational research purposes.

Isenção de responsabilidade

U-62066 (Spiradoline) is supplied strictly for laboratory, analytical, scientific, and educational research purposes only. It is not intended for human consumption, medical treatment, veterinary applications, therapeutic use, or diagnostic procedures. Users are responsible for complying with all applicable local laws, institutional policies, and laboratory safety regulations.