4F-MPH (4-Fluoromethylphenidate), auch bekannt als 4-Fluoro-Methylphenidate oder 4-FMPH, is a synthetic stimulant belonging to the piperidine class of compounds. Structurally related to methylphenidate, 4F-MPH was originally developed and investigated in medicinal chemistry programs exploring dopamine transporter ligands and potential treatments for stimulant dependence.

Today, 4F-MPH is primarily utilized as an Analytischer Referenzstandard in forensic toxicology, medicinal chemistry, neuropharmacology, and analytical laboratory research. Its well-characterized interaction with monoamine transporters makes it valuable for studies involving dopamine transporter function and structure–activity relationships (SAR).

What is 4F-MPH?

4F-MPH is a fluorinated analogue of methylphenidate developed for research into monoamine transporter pharmacology. The addition of a fluorine atom to the aromatic ring alters transporter binding characteristics, making the compound useful for investigating dopamine transporter affinity and medicinal chemistry optimization.

Researchers employ 4F-MPH as an analytical reference standard to study transporter interactions, metabolic pathways, forensic identification, and analytical method development.

Chemische Struktur und Eigenschaften

4F-MPH possesses several defining structural characteristics:

• Piperidine molecular scaffold
• Para-fluorinated aromatic ring
• Ester-Funktionsgruppe
• Hohe Chemische Stabilität
• Geeignetes analytisches Referenzmaterial

These structural features support comparative investigations involving methylphenidate analogues and transporter-selective compounds.

Pharmakologische Forschung

Laboratory investigations indicate that 4F-MPH primarily functions as a dopamine transporter (DAT) Und norepinephrine transporter (NET) inhibitor, reducing monoamine reuptake in experimental systems.

Scientific research has explored 4F-MPH for:

• Dopamintransporter-Bindungsstudien
• Norepinephrine transporter research
• Monoamine transporter pharmacology
• Struktur–Aktivitäts-Beziehung (SAR) Analyse
• Medicinal chemistry optimization
• Vergleichende Stimulanzienforschung

Studies have shown that fluorinated methylphenidate analogues may exhibit increased transporter affinity compared with the parent compound, making 4F-MPH a valuable tool for transporter-focused investigations.

Wissenschaftliche Forschung Anwendungen

4F-MPH is widely used in laboratory environments for:

• Neuropharmacology
• Medizinische Chemie
• Pharmazeutische Entdeckung
• Forensische Toxikologie
• Analytische Chemie
• Dopamine Transporter Research
• Studien zum Drogenstoffwechsel
• Referenz-Standard-Entwicklung
• Academic Neuroscience Research

Analytische Anwendungen

Professional laboratories utilize 4F-MPH reference standards for:

• LC-MS/MS-Analyse
• GC-MS-Identifikation
• Hochleistungsflüssigchromatographie (HPLC)
• High-Resolution Mass Spectrometry (HRMS)
• Toxikologie-Screening
• Methodenvalidierung
• Qualitätskontrolle
• Referenzmaterialkalibrierung

These analytical methods provide reliable identification and differentiation of 4F-MPH from structurally related stimulant compounds.

Why Researchers Study 4F-MPH

4F-MPH contributes to scientific investigations involving:

• Dopamintransporter-Pharmakologie
• Wechselwirkungen zwischen Monoamintransportern
• Medicinal
  • chemistry optimization
  • Structure–activity relationship (SAR) studies
  • forensische analytische Entwicklung
  • Wirkstofffindung
  • Emerging stimulant identification
  • Laborqualitätssicherung

  Its fluorinated structure provides useful insights into transporter binding and molecular design strategies.

  Verwandte Forschungs-Verbindungen

  Researchers frequently compare 4F-MPH with:

  • Methylphenidat
  • Dexmethylphenidate
  • Ethylphenidat
  • 4F-EPH (4-Fluoroethylphenidate)
  • Isopropylphenidate (IPPH)
  • HDMP-28
  • HDEP-28
  • 4-Methylmethylphenidat
  • Other methylphenidate analogues

  Comparative investigations improve understanding of transporter affinity, molecular structure, and analytical differentiation.

  Lagerung und Handhabung

  Für maximale Laborstabilität:

  • Speichern Sie in luftdichten Labor-Container.
  • Vor Feuchtigkeit und Nässe schützen.
  • Avoid prolonged exposure to heat and direct sunlight.
  • Die institutionellen Laborsicherheitsvorschriften sind einzuhalten.
  • Handhabung mit geeigneter persönlicher Schutzausrüstung (PSA).
  • ausschließlich für qualifiziertes Laborpersonal bestimmt.

  Häufig gestellte Fragen

  What is 4F-MPH?

  4F-MPH (4-Fluoromethylphenidate) is a fluorinated methylphenidate analogue used as an analytical reference standard in neuropharmacology, medicinal chemistry, forensic toxicology, and analytical laboratory research.

  Which research fields use 4F-MPH?

  4F-MPH is commonly used in neuroscience, neuropharmacology, pharmaceutical research, medicinal chemistry, analytical chemistry, and forensic toxicology laboratories.

  Which analytical techniques are used with 4F-MPH?

  Researchers commonly analyze 4F-MPH using LC-MS/MS, GC-MS, HPLC, and HRMS for compound identification, calibration, quality assurance, and method validation.

  Why is 4F-MPH valuable for research?

  Its well-characterized interaction with monoamine transporters, fluorinated molecular structure, and relevance to methylphenidate analogue research make it valuable for transporter pharmacology, medicinal chemistry, and analytical investigations.

  Is 4F-MPH intended only for laboratory research?

  Yes. 4F-MPH is supplied exclusively for laboratory, analytical, scientific, forensic, and educational research purposes.

  Haftungsausschluss

  4F-MPH (4-Fluoromethylphenidate) ist beabsichtigt Exklusiv für Labor-, Analyse-, Wissenschafts- und Bildungsforschung. drohen Dieses Produkt ist nicht für den menschlichen Verzehr, medizinische Behandlung, Tierarzneimittel, therapeutische Maßnahmen oder diagnostische Zwecke. drohen Die Benutzer sind für die Einhaltung aller geltenden Gesetze, Vorschriften und institutionellen Sicherheitsanforderungen für das Labor verantwortlich.