4F-MPH (4-Fluorometilfenidato), também conhecida como 4-Fluoro-Methylphenidate ou 4-FMPH, is a synthetic stimulant belonging to the piperidine class of compounds. Structurally related to methylphenidate, 4F-MPH was originally developed and investigated in medicinal chemistry programs exploring dopamine transporter ligands and potential treatments for stimulant dependence.

Today, 4F-MPH is primarily utilized as an padrão de referência analítico in forensic toxicology, medicinal chemistry, neuropharmacology, and analytical laboratory research. Its well-characterized interaction with monoamine transporters makes it valuable for studies involving dopamine transporter function and structure–activity relationships (SAR).

What is 4F-MPH?

4F-MPH is a fluorinated analogue of methylphenidate developed for research into monoamine transporter pharmacology. The addition of a fluorine atom to the aromatic ring alters transporter binding characteristics, making the compound useful for investigating dopamine transporter affinity and medicinal chemistry optimization.

Researchers employ 4F-MPH as an analytical reference standard to study transporter interactions, metabolic pathways, forensic identification, and analytical method development.

Estrutura química e Propriedades

4F-MPH possesses several defining structural characteristics:

• Piperidine molecular scaffold
• Para-fluorinated aromatic ring
• Grupo funcional éster
• Alta estabilidade química
• Material de referência analítico adequado

These structural features support comparative investigations involving methylphenidate analogues and transporter-selective compounds.

Investigação Farmacológica

Laboratory investigations indicate that 4F-MPH primarily functions as a dopamine transporter (DAT) e norepinephrine transporter (NET) inhibitor, reducing monoamine reuptake in experimental systems.

Scientific research has explored 4F-MPH for:

• estudos de ligação do transportador de dopamina
• Norepinephrine transporter research
• Monoamine transporter pharmacology
• Relação estrutura–atividade (SAR) de análise
• Química Medicinal otimização
• Investigação comparativa de estimulantes

Studies have shown that fluorinated methylphenidate analogues may exhibit increased transporter affinity compared with the parent compound, making 4F-MPH a valuable tool for transporter-focused investigations.

A Investigação Científica Aplicações

4F-MPH is widely used in laboratory environments for:

• Neurofarmacologia
• Química Medicinal
• Descoberta farmacêutica
• toxicologia forense
• Química Analítica
• Dopamine Transporter Research
• Estudos de metabolismo de fármacos
• Padrão De Referência De Desenvolvimento
• Academic Neuroscience Research

Aplicações Analíticas

Professional laboratories utilize 4F-MPH reference standards for:

• Análise LC-MS/MS
• Identificação por GC-MS
• Cromatografia Líquida de Alto Desempenho (HPLC)
• De alta Resolução de Espectrometria de Massa (HRMS)
• Triagem toxicológica
• Validação do método
• Controlo de qualidade
• Calibração do Material de Referência

These analytical methods provide reliable identification and differentiation of 4F-MPH from structurally related stimulant compounds.

Why Researchers Study 4F-MPH

4F-MPH contributes to scientific investigations involving:

• Farmacologia do transportador de dopamina
• Interações do transportador de monoamina
• Medicinal
  • chemistry optimization
  • Estudos estrutura-atividade (SAR)
  • Desenvolvimento analítico forense
  • Descoberta de compostos líderes farmacêuticos
  • Emerging stimulant identification
  • Garantia de qualidade laboratorial

  Its fluorinated structure provides useful insights into transporter binding and molecular design strategies.

  A Investigação Relacionada Com Compostos

  Researchers frequently compare 4F-MPH with:

  • Metilfenidato
  • Dexmetilfenidato
  • Etilfenidato
  • 4F-EPH (4-Fluoroethylphenidate)
  • Isopropylphenidate (IPPH)
  • HDMP-28
  • HDEP-28
  • 4-Metilmetilfenidato
  • Other methylphenidate analogues

  Comparative investigations improve understanding of transporter affinity, molecular structure, and analytical differentiation.

  Armazenamento e Manipulação

  Para máxima estabilidade laboratorial:

  • Loja em hermético recipientes de laboratório.
  • Proteger da humidade e do bolor.
  • Avoid prolonged exposure to heat and direct sunlight.
  • Siga os protocolos institucionais de segurança laboratorial.
  • Manusear utilizando equipamento de proteção individual (EPI) adequado.
  • Destinado exclusivamente a pessoal de laboratório qualificado.

  Perguntas frequentes

  What is 4F-MPH?

  4F-MPH (4-Fluoromethylphenidate) is a fluorinated methylphenidate analogue used as an analytical reference standard in neuropharmacology, medicinal chemistry, forensic toxicology, and analytical laboratory research.

  Which research fields use 4F-MPH?

  4F-MPH is commonly used in neuroscience, neuropharmacology, pharmaceutical research, medicinal chemistry, analytical chemistry, and forensic toxicology laboratories.

  Which analytical techniques are used with 4F-MPH?

  Researchers commonly analyze 4F-MPH using LC-MS/MS, GC-MS, HPLC, and HRMS for compound identification, calibration, quality assurance, and method validation.

  Why is 4F-MPH valuable for research?

  Its well-characterized interaction with monoamine transporters, fluorinated molecular structure, and relevance to methylphenidate analogue research make it valuable for transporter pharmacology, medicinal chemistry, and analytical investigations.

  Is 4F-MPH intended only for laboratory research?

  Yes. 4F-MPH is supplied exclusively for laboratory, analytical, scientific, forensic, and educational research purposes.

  Isenção de responsabilidade

  4F-MPH (4-Fluorometilfenidato) é pretendido exclusivamente para a área laboratorial, analítico, científico e de investigação educacional. Este produto é não destinados ao consumo humano, tratamento médico, veterinário, aplicações terapêuticas, ou para fins de diagnósticoOs utilizadores são responsáveis ​​pelo cumprimento de todas as leis, regulamentos e requisitos institucionais de segurança laboratorial aplicáveis.