4F-MPH (4-fluorometilfenidato), también conocido como 4-Fluoro-Methylphenidate o 4-FMPH, is a synthetic stimulant belonging to the piperidine class of compounds. Structurally related to methylphenidate, 4F-MPH was originally developed and investigated in medicinal chemistry programs exploring dopamine transporter ligands and potential treatments for stimulant dependence.

Today, 4F-MPH is primarily utilized as an Estándar de referencia analítico in forensic toxicology, medicinal chemistry, neuropharmacology, and analytical laboratory research. Its well-characterized interaction with monoamine transporters makes it valuable for studies involving dopamine transporter function and structure–activity relationships (SAR).

What is 4F-MPH?

4F-MPH is a fluorinated analogue of methylphenidate developed for research into monoamine transporter pharmacology. The addition of a fluorine atom to the aromatic ring alters transporter binding characteristics, making the compound useful for investigating dopamine transporter affinity and medicinal chemistry optimization.

Researchers employ 4F-MPH as an analytical reference standard to study transporter interactions, metabolic pathways, forensic identification, and analytical method development.

Estructura y Propiedades químicas

4F-MPH possesses several defining structural characteristics:

• Piperidine molecular scaffold
• Para-fluorinated aromatic ring
• Grupo funcional éster
• Alta estabilidad química
• Material de referencia analítico adecuado

These structural features support comparative investigations involving methylphenidate analogues and transporter-selective compounds.

La Investigación Farmacológica

Laboratory investigations indicate that 4F-MPH primarily functions as a dopamine transporter (DAT) and norepinephrine transporter (NET) inhibitor, reducing monoamine reuptake in experimental systems.

Scientific research has explored 4F-MPH for:

• Estudios de unión del transportador de dopamina
• Norepinephrine transporter research
• Monoamine transporter pharmacology
• Relación estructura–actividad (SAR), el análisis
• La química Medicinal de la optimización de la
• Investigación comparativa sobre estimulantes

Studies have shown that fluorinated methylphenidate analogues may exhibit increased transporter affinity compared with the parent compound, making 4F-MPH a valuable tool for transporter-focused investigations.

Las Aplicaciones De La Investigación Científica

4F-MPH is widely used in laboratory environments for:

• Neurofarmacología
• La Química Medicinal
• Descubrimiento far
• Toxicología forense
• Química Analítica
• Dopamine Transporter Research
• Estudios de metabolismo de drogas
• Estándar De Referencia De Desarrollo
• Academic Neuroscience Research

Aplicaciones Analíticas

Professional laboratories utilize 4F-MPH reference standards for:

• Análisis LC-MS/MS
• Identificación de GC-MS
• Cromatografía líquida de alto rendimiento (HPLC)
• De alta Resolución y Espectrometría de Masa (HRMS)
• Detección de toxicología
• Validación de métodos
• control de calidad
• Calibración de material de referencia

These analytical methods provide reliable identification and differentiation of 4F-MPH from structurally related stimulant compounds.

Why Researchers Study 4F-MPH

4F-MPH contributes to scientific investigations involving:

• Farmacología del transportador de dopamina
• Interacciones del transportador de monoaminas.
• Medicinal
  • chemistry optimization
  • Estudios de relación estructura-actividad (SAR)
  • desarrollo analítico forense
  • Pharmaceutical lead discovery
  • Emerging stimulant identification
  • Garantía de calidad de laboratorio

  Its fluorinated structure provides useful insights into transporter binding and molecular design strategies.

  La Investigación Relacionada Con Los Compuestos

  Researchers frequently compare 4F-MPH with:

  • Metilfenidato
  • Dexmetilfenidato
  • etilfenidato
  • 4F-EPH (4-Fluoroethylphenidate)
  • Isopropylphenidate (IPPH)
  • HDMP-28
  • HDEP-28
  • 4-Metilmetilfenidato
  • Other methylphenidate analogues

  Comparative investigations improve understanding of transporter affinity, molecular structure, and analytical differentiation.

  El almacenamiento y la Manipulación

  Para una máxima estabilidad de laboratorio:

  • Tienda en herméticos recipientes de laboratorio.
  • Proteger de la humedad.
  • Avoid prolonged exposure to heat and direct sunlight.
  • Siga los protocolos de seguridad del laboratorio institucional.
  • Manipule con el equipo de protección personal (PPE) apropiado.
  • Destinado exclusivamente a personal de laboratorio calificado.

  Preguntas frecuentes

  What is 4F-MPH?

  4F-MPH (4-Fluoromethylphenidate) is a fluorinated methylphenidate analogue used as an analytical reference standard in neuropharmacology, medicinal chemistry, forensic toxicology, and analytical laboratory research.

  Which research fields use 4F-MPH?

  4F-MPH is commonly used in neuroscience, neuropharmacology, pharmaceutical research, medicinal chemistry, analytical chemistry, and forensic toxicology laboratories.

  Which analytical techniques are used with 4F-MPH?

  Researchers commonly analyze 4F-MPH using LC-MS/MS, GC-MS, HPLC, and HRMS for compound identification, calibration, quality assurance, and method validation.

  Why is 4F-MPH valuable for research?

  Its well-characterized interaction with monoamine transporters, fluorinated molecular structure, and relevance to methylphenidate analogue research make it valuable for transporter pharmacology, medicinal chemistry, and analytical investigations.

  Is 4F-MPH intended only for laboratory research?

  Yes. 4F-MPH is supplied exclusively for laboratory, analytical, scientific, forensic, and educational research purposes.

  Descargo de responsabilidad

  4F-MPH (4-fluorometilfenidato) es destinado Exclusivamente para investigación de laboratorio, analítica, científica y educativa. Este producto es no destinados al consumo humano, el tratamiento médico, la medicina veterinaria, aplicaciones terapéuticas, o con fines de diagnóstico. Los usuarios son responsables de cumplir con todas las leyes, regulaciones y requisitos de seguridad de laboratorio institucionales aplicables.