CRL-40,941allgemein bekannt als Fladrafinil oder Bisfluoroadrafinilist ein hochreines eugeroic (wakefulness-promoting) research chemical belonging to the diphenylmethyl sulfinyl acetamide family. Developed by Laboratoire Lafon during investigations into next-generation wakefulness-promoting compounds, Fladrafinil is a fluorinated analogue of Adrafinil and is closely related to Modafinil Und Flmodafinil (CRL-40,940).

Although never approved as a pharmaceutical medication, CRL-40,941 has become an important analytical reference material for laboratories studying wakefulness-promoting agents, dopamine transporter pharmacology, medicinal chemistry, metabolism, and neuropharmacology.

What is CRL-40,941 (Fladrafinil)?

Fladrafinil is a fluorinated derivative of Adrafinil developed during research into compounds that promote wakefulness and cognitive function. Structurally, it differs from Adrafinil by the addition of fluorine atoms on both aromatic rings, a modification used in medicinal chemistry to investigate how halogen substitution affects pharmacological properties, metabolic stability, and receptor interactions.

Because of its defined chemical profile, CRL-40,941 is widely used as a reference standard in analytical laboratories and pharmaceutical research.

Chemische Struktur und Eigenschaften

CRL-40,941 contains several notable structural features:

• Diphenylmethyl sulfoxide core
• Hydroxamic acid functionality
• Two para-fluorophenyl rings
• Sulfinyl linkage
• Hohe Chemische Stabilität
• Kristallines Laborpulver

These characteristics make it useful for chromatographic analysis, analytical validation, and medicinal chemistry investigations.

Pharmakologische Forschung

Scientific literature indicates that Fladrafinil belongs to the same pharmacological family as Modafinil and Adrafinil. Research suggests that compounds within this family influence dopamine transporter (DAT) activity, making them valuable tools for studying wakefulness mechanisms and central nervous system pharmacology.

Current research areas include:

• Dopamine transporter (DAT) investigations
• Wakefulness-promoting compound research
• Neurochemical signaling
• Cognitive enhancer pharmacology
• Comparative studies with Modafinil analogues
• Struktur–Aktivitäts-Beziehung (SAR) Analyse
• Drug metabolism and pharmacokinetics

Animal studies have also explored behavioral effects, including wakefulness and anti-aggressive activity, although further research is needed to fully characterize its pharmacological profile.

Wissenschaftliche Forschung Anwendungen

CRL-40,941 is frequently used in:

• Pharmazeutische Entwicklung
• Labore für medizinische Chemie
• Neurpharmakologie-Forschung
• Academic neuroscience
• Analytische Chemie
• Droge Metabolismus-Untersuchungen
• Forensische Toxikologie
• Referenzstandardproduktion
• Qualitätskontrolllaboratorien

Analytische Anwendungen

Researchers utilize Fladrafinil for:

• LC-MS/MS method development
• GC-MS analytical calibration
• HPLC-Analyse
• Hochauflösende Massenspektrometrie (HRMS)
• Erstellung von Referenzbibliotheken
• Methodenvalidierung
• Identifizierung von Verbindungen
• Stability testing
• Quality assurance protocols

Its well-defined analytical profile supports accurate differentiation from related compounds such as Modafinil, Adrafinil, and Flmodafinil.

Why Researchers Choose CRL-40,941

Researchers value Fladrafinil because it offers:

• Gut charakterisierten molekularen Struktur
• Hohe analytische Reinheit
• Zuverlässige chromatographische Verhalten
• Ausgezeichnete analytische Reproduzierbarkeit
• Useful SAR comparison with Modafinil analogues
• Broad application in neuropharmacology
• Gleichbleibende Laborleistung

Verwandte Forschungs-Verbindungen

Fladrafinil is commonly studied alongside:

• Modafinil
• Armodafinil
• Adrafinil
• Flmodafinil (CRL-40,940)
• CE-123
• Modafinil analogues
• Eugeroic research compounds

Comparative investigations help researchers understand transporter interactions, metabolism, and structural modifications within the eugeroic class.

Lagerung und Handhabung

Für eine optimale Labor-Stabilität:

• Speichern Sie in luftdichten Labor-Container.
• Vor Feuchtigkeit und Nässe schützen.
• Keep away from direct sunlight.
• Pflegen empfohlen Labor-Lagerung Temperaturen.
• Bei der Handhabung ist geeignete Laborschutzausrüstung (PSA) zu verwenden.
• Folgen institutionellen Labor-Sicherheits-Verfahren.

Häufig gestellte Fragen

What is CRL-40,941?

CRL-40,941 (Fladrafinil) is a fluorinated analogue of Adrafinil used as an analytical reference standard in neuropharmacology, medicinal chemistry, pharmaceutical research, and forensic toxicology.

Which laboratories use Fladrafinil?

It is commonly used by pharmaceutical companies, forensic laboratories, academic institutions, medicinal chemists, and analytical chemistry laboratories.

Which analytical techniques are suitable for CRL-40,941?

Researchers commonly analyze Fladrafinil using LC-MS/MS, GC-MS, HPLC, and HRMS for calibration, compound identification, and analytical method validation.

Why is Fladrafinil valuable for research?

Its defined molecular structure, relationship to Modafinil analogues, and analytical consistency make it useful for pharmacological research, transporter studies, and medicinal chemistry investigations.

Is CRL-40,941 intended only for research?

Ja. Dieses Produkt ist ausschließlich für Labor, analytischen, wissenschaftlichen, Bildungs-und wissenschaftliche Zwecke.

Haftungsausschluss

CRL-40,941 (Fladrafinil) geliefert wird ausschließlich für Labor-, Analyse-, wissenschaftliche und pädagogische Forschungszwecke. Es ist not intended for human consumption, therapeutic use, veterinary applications, medical treatment, or diagnostic purposes. Researchers are responsible for complying with all applicable laws, institutional policies, and laboratory safety regulations.