CRL-40,941, communément appelé Fladrafinil ou Bisfluoroadrafinil, est d'une grande pureté eugeroic (wakefulness-promoting) research chemical belonging to the diphenylmethyl sulfinyl acetamide family. Developed by Laboratoire Lafon during investigations into next-generation wakefulness-promoting compounds, Fladrafinil is a fluorinated analogue of Adrafinil and is closely related to Modafinil et Flmodafinil (CRL-40,940).

Although never approved as a pharmaceutical medication, CRL-40,941 has become an important analytical reference material for laboratories studying wakefulness-promoting agents, dopamine transporter pharmacology, medicinal chemistry, metabolism, and neuropharmacology.

What is CRL-40,941 (Fladrafinil)?

Fladrafinil is a fluorinated derivative of Adrafinil developed during research into compounds that promote wakefulness and cognitive function. Structurally, it differs from Adrafinil by the addition of fluorine atoms on both aromatic rings, a modification used in medicinal chemistry to investigate how halogen substitution affects pharmacological properties, metabolic stability, and receptor interactions.

Because of its defined chemical profile, CRL-40,941 is widely used as a reference standard in analytical laboratories and pharmaceutical research.

La Structure chimique et les Propriétés

CRL-40,941 contains several notable structural features:

• Diphenylmethyl sulfoxide core
• Hydroxamic acid functionality
• Two para-fluorophenyl rings
• Sulfinyl linkage
• Haute stabilité chimique
• Poudre de qualité laboratoire cristalline

These characteristics make it useful for chromatographic analysis, analytical validation, and medicinal chemistry investigations.

La Recherche Pharmacologique

Scientific literature indicates that Fladrafinil belongs to the same pharmacological family as Modafinil and Adrafinil. Research suggests that compounds within this family influence Transporteur de dopamine (DAT) activity, making them valuable tools for studying wakefulness mechanisms and central nervous system pharmacology.

Current research areas include:

• Dopamine transporter (DAT) investigations
• Wakefulness-promoting compound research
• Neurochemical signaling
• Cognitive enhancer pharmacology
• Comparative studies with Modafinil analogues
• Relation Structure–activité (SAR) analyse
• Drug metabolism and pharmacokinetics

Animal studies have also explored behavioral effects, including wakefulness and anti-aggressive activity, although further research is needed to fully characterize its pharmacological profile.

Les Applications Scientifiques

CRL-40,941 is frequently used in:

• développement pharmaceutique
• Laboratoires de chimie médicinale
• Recherche en neuropharmacologie
• Universitaire en neurosciences
• Chimie analytique
• Le métabolisme des médicaments enquêtes
• Toxicologie médico-légale
• Norme de référence de la production
• Laboratoire de contrôle de qualité

Applications Analytiques De

Researchers utilize Fladrafinil for:

• LC-MS/MS method development
• GC-MS analytical calibration
• analyse HPLC
• Spectrométrie de masse à haute résolution (HRMS)
• Création d'une bibliothèque de référence
• Validation de la méthode
• Identification du composé
• Stability testing
• Quality assurance protocols

Its well-defined analytical profile supports accurate differentiation from related compounds such as Modafinil, Adrafinil, and Flmodafinil.

Why Researchers Choose CRL-40,941

Researchers value Fladrafinil because it offers:

• Bien caractérisé la structure moléculaire
• Haute pureté analytique
• Comportement chromatographique fiable
• Excellente reproductibilité analytique
• Useful SAR comparison with Modafinil analogues
• Broad application in neuropharmacology
• Performances constantes en laboratoire

Recherche Liée À Des Composés

Fladrafinil is commonly studied alongside:

• Modafinil
• Armodafinil
• Adrafinil
• Flmodafinil (CRL-40,940)
• CE-123
• Modafinil analogues
• Eugeroic research compounds

Comparative investigations help researchers understand transporter interactions, metabolism, and structural modifications within the eugeroic class.

De stockage et de Manutention

Pour optimiser le laboratoire de la stabilité:

• Magasin étanche à l'air dans les récipients de laboratoire.
• Protéger de l'humidité.
• Keep away from direct sunlight.
• Maintenir recommandé de laboratoire températures de stockage.
• Manipuler en utilisant un équipement de protection individuelle (EPI) de laboratoire approprié.
• Suivez laboratoire institutionnel procédures de sécurité.

Foire aux questions

What is CRL-40,941?

CRL-40,941 (Fladrafinil) is a fluorinated analogue of Adrafinil used as an analytical reference standard in neuropharmacology, medicinal chemistry, pharmaceutical research, and forensic toxicology.

Which laboratories use Fladrafinil?

It is commonly used by pharmaceutical companies, forensic laboratories, academic institutions, medicinal chemists, and analytical chemistry laboratories.

Which analytical techniques are suitable for CRL-40,941?

Researchers commonly analyze Fladrafinil using LC-MS/MS, GC-MS, HPLC, and HRMS for calibration, compound identification, and analytical method validation.

Why is Fladrafinil valuable for research?

Its defined molecular structure, relationship to Modafinil analogues, and analytical consistency make it useful for pharmacological research, transporter studies, and medicinal chemistry investigations.

Is CRL-40,941 intended only for research?

Oui. Ce produit est fourni exclusivement pour le laboratoire, analytique, scientifique, et de l'enseignement des fins de recherche.

Avertissement

CRL-40,941 (Fladrafinil) est fourni uniquement à des fins de recherche en laboratoire, analytiques, scientifiques et pédagogiques. Il est not intended for human consumption, therapeutic use, veterinary applications, medical treatment, or diagnostic purposes. Researchers are responsible for complying with all applicable laws, institutional policies, and laboratory safety regulations.