CRL-40,941, vulgarmente conhecido como Fladrafinil ou Bisfluoroadrafinilé um alto grau de pureza eugeroic (wakefulness-promoting) research chemical belonging to the diphenylmethyl sulfinyl acetamide family. Developed by Laboratoire Lafon during investigations into next-generation wakefulness-promoting compounds, Fladrafinil is a fluorinated analogue of Adrafinil and is closely related to Modafinil e Flmodafinil (CRL-40,940).

Although never approved as a pharmaceutical medication, CRL-40,941 has become an important analytical reference material for laboratories studying wakefulness-promoting agents, dopamine transporter pharmacology, medicinal chemistry, metabolism, and neuropharmacology.

What is CRL-40,941 (Fladrafinil)?

Fladrafinil is a fluorinated derivative of Adrafinil developed during research into compounds that promote wakefulness and cognitive function. Structurally, it differs from Adrafinil by the addition of fluorine atoms on both aromatic rings, a modification used in medicinal chemistry to investigate how halogen substitution affects pharmacological properties, metabolic stability, and receptor interactions.

Because of its defined chemical profile, CRL-40,941 is widely used as a reference standard in analytical laboratories and pharmaceutical research.

Estrutura química e Propriedades

CRL-40,941 contains several notable structural features:

• Diphenylmethyl sulfoxide core
• Hydroxamic acid functionality
• Two para-fluorophenyl rings
• Sulfinyl linkage
• Alta estabilidade química
• Pó cristalino de grau laboratorial

These characteristics make it useful for chromatographic analysis, analytical validation, and medicinal chemistry investigations.

Investigação Farmacológica

Scientific literature indicates that Fladrafinil belongs to the same pharmacological family as Modafinil and Adrafinil. Research suggests that compounds within this family influence dopamine transporter (DAT) activity, making them valuable tools for studying wakefulness mechanisms and central nervous system pharmacology.

Current research areas include:

• Dopamine transporter (DAT) investigations
• Wakefulness-promoting compound research
• Neurochemical signaling
• Cognitive enhancer pharmacology
• Comparative studies with Modafinil analogues
• Relação estrutura–atividade (SAR) de análise
• Drug metabolism and pharmacokinetics

Animal studies have also explored behavioral effects, including wakefulness and anti-aggressive activity, although further research is needed to fully characterize its pharmacological profile.

A Investigação Científica Aplicações

CRL-40,941 is frequently used in:

• Desenvolvimento farmacêutico
• Laboratórios de química medicinal
• Investigação em neurofarmacologia
• Acadêmica de neurociência
• Química analítica
• Investigações sobre o metabolismo dos fármacos
• Toxicologia forense
• Padrão de referência de produção
• Laboratórios de controle de qualidade

Aplicações Analíticas

Researchers utilize Fladrafinil for:

• LC-MS/MS method development
• GC-MS analytical calibration
• Análise por HPLC
• Espectrometria de massas de alta resolução (HRMS)
• Criação de biblioteca de referência
• Validação do método
• Identificação do composto
• Stability testing
• Quality assurance protocols

Its well-defined analytical profile supports accurate differentiation from related compounds such as Modafinil, Adrafinil, and Flmodafinil.

Why Researchers Choose CRL-40,941

Researchers value Fladrafinil because it offers:

• Bem-caracteriza-se a estrutura molecular
• De alta pureza analítica
• Comportamento cromatográfico fiável
• Excelente reprodutibilidade analítica
• Useful SAR comparison with Modafinil analogues
• Broad application in neuropharmacology
• Desempenho consistente em laboratório

A Investigação Relacionada Com Compostos

Fladrafinil is commonly studied alongside:

• Modafinil
• Armodafinil
• Adrafinil
• Flmodafinil (CRL-40,940)
• CE-123
• Modafinil analogues
• Eugeroic research compounds

Comparative investigations help researchers understand transporter interactions, metabolism, and structural modifications within the eugeroic class.

Armazenamento e Manipulação

Para um óptimo laboratório de estabilidade:

• Loja em hermético recipientes de laboratório.
• Proteger da humidade e do bolor.
• Keep away from direct sunlight.
• Manter recomendada laboratório de temperaturas de armazenamento.
• Manusear utilizando equipamento de proteção individual (EPI) de laboratório apropriado.
• Siga institucionais laboratório de procedimentos de segurança.

Perguntas frequentes

What is CRL-40,941?

CRL-40,941 (Fladrafinil) is a fluorinated analogue of Adrafinil used as an analytical reference standard in neuropharmacology, medicinal chemistry, pharmaceutical research, and forensic toxicology.

Which laboratories use Fladrafinil?

It is commonly used by pharmaceutical companies, forensic laboratories, academic institutions, medicinal chemists, and analytical chemistry laboratories.

Which analytical techniques are suitable for CRL-40,941?

Researchers commonly analyze Fladrafinil using LC-MS/MS, GC-MS, HPLC, and HRMS for calibration, compound identification, and analytical method validation.

Why is Fladrafinil valuable for research?

Its defined molecular structure, relationship to Modafinil analogues, and analytical consistency make it useful for pharmacological research, transporter studies, and medicinal chemistry investigations.

Is CRL-40,941 intended only for research?

Sim. Este produto é fornecido exclusivamente para a área laboratorial, analítico, científico e educacional fins de pesquisa.

Isenção de responsabilidade

CRL-40,941 (Fladrafinil) é fornecido estritamente para fins de investigação laboratorial, analítica, científica e educacional.. É not intended for human consumption, therapeutic use, veterinary applications, medical treatment, or diagnostic purposes. Researchers are responsible for complying with all applicable laws, institutional policies, and laboratory safety regulations.