Bromazolam (XLI-268) is a high-potency triazolobenzodiazepine (TBZD) research chemical that belongs to the benzodiazepine family. First synthesized in 1976, Bromazolam was originally investigated for pharmaceutical research but was never approved for medical use. Today, it is primarily utilized as an Estándar de referencia analítico for forensic toxicology, pharmacology, medicinal chemistry, and analytical laboratory research.

Due to its structural similarity to alprazolam, Bromazolam is widely studied for receptor-binding characteristics, metabolic profiling, and analytical method development.

What is Bromazolam?

Bromazolam is a laboratory-produced triazolobenzodiazepine developed for scientific investigation of benzodiazepine receptor pharmacology. It shares close structural similarities with alprazolam while containing a bromine substitution that makes it valuable for analytical differentiation and forensic identification.

Researchers utilize Bromazolam as a certified reference material when studying emerging benzodiazepine analogues, metabolic pathways, and analytical detection techniques.

Estructura y Propiedades químicas

Bromazolam possesses several defining structural characteristics:

• Triazolobenzodiazepine core
• Anillo aromático bromado
• High chemical purity
• Stable crystalline structure
• Material de referencia analítico adecuado

These characteristics make Bromazolam an important compound for benzodiazepine research and laboratory analysis.

La Investigación Farmacológica

Laboratory studies indicate Bromazolam functions as a positive allosteric modulator of the GABAA receptor, interacting with the benzodiazepine binding site.

Scientific investigations have demonstrated high affinity toward multiple GABAA receptor subtypes, making Bromazolam useful for:

• Estudios de unión a receptores
• Pharmacodynamic research
• Neuropharmacology investigations
• Análisis de relación estructura-actividad (SAR)
• Investigación comparativa sobre benzodiazepinas

Its receptor profile provides valuable information for medicinal chemistry and neuroscience research.

Metabolism Research

Bromazolam has been extensively investigated in human liver microsome and hepatocyte studies.

Major metabolic pathways include:

• Hydroxylation
• Dihydroxylation
• Glucuronidation
• Phase I metabolism
• Phase II metabolism

Reported metabolites include:

• Phenyl-hydroxy Bromazolam
• 4-Hydroxy Bromazolam
• Alpha-hydroxy Bromazolam
• Alpha-4-dihydroxy Bromazolam
• Bromazolam N-glucuronide
• Hydroxy Bromazolam glucuronides

These metabolites assist forensic laboratories in biological sample identification and toxicological investigations.

Las Aplicaciones De La Investigación Científica

Bromazolam is commonly used in:

• Toxicología forense
• química medicinal
• Pharmaceutical Research
• Neurofarmacología
• química analítica
• GABAA receptor research
• Estándar de referencia de la producción
• Metabolismo de los fármacos estudios
• Structure–Activity Relationship (SAR) research

Aplicaciones Analíticas

Professional laboratories utilize Bromazolam for:

• Análisis LC-MS/MS
• Identificación de GC-MS
• HPLC Analysis
• De alta Resolución y Espectrometría de Masa (HRMS)
• Detección de toxicología
• Reference Standard Calibration
• Validación de métodos
• Quality Control Testing

These analytical methods enable accurate detection and identification of Bromazolam in research environments.

Why Researchers Study Bromazolam

Bromazolam supports numerous laboratory investigations involving:

• Benzodiazepine analogue identification
• La química Medicinal de la optimización de la
• Pharmaceutical compound development
• Forensic casework
• Analytical method validation
• Caracterización de la vía metabólica
• Receptor pharmacology
• Garantía de calidad de laboratorio

Its well-characterized structure makes it valuable for comparative studies involving triazolobenzodiazepines.

La Investigación Relacionada Con Los Compuestos

Researchers frequently compare Bromazolam with:

• Alprazolam
• Clonazolam
• flubromazola
• Flualprazolam
• Etizolam
• Diazepam
• Midazolam
• Triazolam
• Other benzodiazepine analogues

Comparative investigations help improve analytical differentiation and pharmacological characterization.

El almacenamiento y la Manipulación

Para una óptima laboratorio de estabilidad:

• Tienda en herméticos recipientes de laboratorio.
• Keep away from moisture and humidity.
• Avoid prolonged light exposure.
• Mantener recomendados laboratorio de temperaturas de almacenamiento.
• Manejar el uso apropiado de laboratorio equipo de protección personal.
• Destinado únicamente a personal de laboratorio cualificado.

Preguntas Frecuentes

What is Bromazolam?

Bromazolam is a triazolobenzodiazepine research chemical used as an analytical reference standard in forensic toxicology, medicinal chemistry, pharmacology, and analytical laboratories.

Which research fields use Bromazolam?

Bromazolam is widely used in forensic toxicology, pharmaceutical research, neuropharmacology, medicinal chemistry, analytical chemistry, and academic laboratory research.

Which analytical techniques are used with Bromazolam?

Researchers commonly analyze Bromazolam using LC-MS/MS, GC-MS, HPLC, and HRMS for compound identification, calibration, quality assurance, and method validation.

Why is Bromazolam valuable for research?

Its well-characterized receptor affinity, metabolic profile, and structural similarity to alprazolam make it valuable for analytical chemistry, forensic investigations, and medicinal chemistry research.

Is Bromazolam intended only for laboratory research?

Yes. Bromazolam is supplied exclusively for laboratory, scientific, analytical, forensic, and educational research purposes.

Descargo de responsabilidad

Bromazolam (XLI-268) es destinado Exclusivamente para investigación de laboratorio, analítica, científica y educativa. Este producto es no destinados al consumo humano, el tratamiento médico, la medicina veterinaria, aplicaciones terapéuticas, o con fines de diagnóstico. Los usuarios son responsables de cumplir con todas las leyes, regulaciones y requisitos de seguridad de laboratorio institucionales aplicables.