Bromazolam (XLI-268) is a high-potency triazolobenzodiazepine (TBZD) research chemical that belongs to the benzodiazepine family. First synthesized in 1976, Bromazolam was originally investigated for pharmaceutical research but was never approved for medical use. Today, it is primarily utilized as an analytical reference standard for forensic toxicology, pharmacology, medicinal chemistry, and analytical laboratory research.

Due to its structural similarity to alprazolam, Bromazolam is widely studied for receptor-binding characteristics, metabolic profiling, and analytical method development.

What is Bromazolam?

Bromazolam is a laboratory-produced triazolobenzodiazepine developed for scientific investigation of benzodiazepine receptor pharmacology. It shares close structural similarities with alprazolam while containing a bromine substitution that makes it valuable for analytical differentiation and forensic identification.

Researchers utilize Bromazolam as a certified reference material when studying emerging benzodiazepine analogues, metabolic pathways, and analytical detection techniques.

Estrutura química e Propriedades

Bromazolam possesses several defining structural characteristics:

• Triazolobenzodiazepine core
• Brominated aromatic ring
• High chemical purity
• Stable crystalline structure
• Material de referência analítico adequado

These characteristics make Bromazolam an important compound for benzodiazepine research and laboratory analysis.

Investigação Farmacológica

Laboratory studies indicate Bromazolam functions as a positive allosteric modulator of the GABAA receptor, interacting with the benzodiazepine binding site.

Scientific investigations have demonstrated high affinity toward multiple GABAA receptor subtypes, making Bromazolam useful for:

• Estudos de ligação ao recetor
• Pharmacodynamic research
• Neuropharmacology investigations
• Análise da relação estrutura-atividade (SAR)
• Investigação comparativa sobre benzodiazepínicos

Its receptor profile provides valuable information for medicinal chemistry and neuroscience research.

Metabolism Research

Bromazolam has been extensively investigated in human liver microsome and hepatocyte studies.

Major metabolic pathways include:

• Hydroxylation
• Dihydroxylation
• Glucuronidation
• Phase I metabolism
• Phase II metabolism

Reported metabolites include:

• Phenyl-hydroxy Bromazolam
• 4-Hydroxy Bromazolam
• Alpha-hydroxy Bromazolam
• Alpha-4-dihydroxy Bromazolam
• Bromazolam N-glucuronide
• Hydroxy Bromazolam glucuronides

These metabolites assist forensic laboratories in biological sample identification and toxicological investigations.

A Investigação Científica Aplicações

Bromazolam is commonly used in:

• toxicologia forense
• química medicinal
• pesquisa farmacêutica
• Neurofarmacologia
• química analítica
• GABAA receptor research
• Padrão de referência de produção
• Metabolismo dos fármacos estudos
• Structure–Activity Relationship (SAR) research

Aplicações Analíticas

Professional laboratories utilize Bromazolam for:

• Análise LC-MS/MS
• Identificação por GC-MS
• HPLC Analysis
• De alta Resolução de Espectrometria de Massa (HRMS)
• Triagem toxicológica
• Reference Standard Calibration
• Validação do método
• Quality Control Testing

These analytical methods enable accurate detection and identification of Bromazolam in research environments.

Why Researchers Study Bromazolam

Bromazolam supports numerous laboratory investigations involving:

• Benzodiazepine analogue identification
• Química Medicinal otimização
• Pharmaceutical compound development
• Forensic casework
• Validação de métodos analíticos
• Caracterização de vias metabólicas
• Receptor pharmacology
• Garantia de qualidade laboratorial

Its well-characterized structure makes it valuable for comparative studies involving triazolobenzodiazepines.

A Investigação Relacionada Com Compostos

Researchers frequently compare Bromazolam with:

• Alprazolam
• Clonazolam
• Flubromazolam
• Flualprazolam
• Etizolam
• Diazepam
• Midazolam
• Triazolam
• Other benzodiazepine analogues

Comparative investigations help improve analytical differentiation and pharmacological characterization.

Armazenamento e Manipulação

Para um óptimo laboratório de estabilidade:

• Loja em hermético recipientes de laboratório.
• Keep away from moisture and humidity.
• Avoid prolonged light exposure.
• Manter recomendada laboratório de temperaturas de armazenamento.
• Identificador usando laboratório adequado de EPI.
• Destinado exclusivamente a pessoal de laboratório qualificado.

Perguntas Frequentes

What is Bromazolam?

Bromazolam is a triazolobenzodiazepine research chemical used as an analytical reference standard in forensic toxicology, medicinal chemistry, pharmacology, and analytical laboratories.

Which research fields use Bromazolam?

Bromazolam is widely used in forensic toxicology, pharmaceutical research, neuropharmacology, medicinal chemistry, analytical chemistry, and academic laboratory research.

Which analytical techniques are used with Bromazolam?

Researchers commonly analyze Bromazolam using LC-MS/MS, GC-MS, HPLC, and HRMS for compound identification, calibration, quality assurance, and method validation.

Why is Bromazolam valuable for research?

Its well-characterized receptor affinity, metabolic profile, and structural similarity to alprazolam make it valuable for analytical chemistry, forensic investigations, and medicinal chemistry research.

Is Bromazolam intended only for laboratory research?

Yes. Bromazolam is supplied exclusively for laboratory, scientific, analytical, forensic, and educational research purposes.

Isenção de responsabilidade

Bromazolam (XLI-268) é pretendido exclusivamente para a área laboratorial, analítico, científico e de investigação educacional. Este produto é não destinados ao consumo humano, tratamento médico, veterinário, aplicações terapêuticas, ou para fins de diagnósticoOs utilizadores são responsáveis ​​pelo cumprimento de todas as leis, regulamentos e requisitos institucionais de segurança laboratorial aplicáveis.