Bromazolam (XLI-268) is a high-potency triazolobenzodiazepine (TBZD) research chemical that belongs to the benzodiazepine family. First synthesized in 1976, Bromazolam was originally investigated for pharmaceutical research but was never approved for medical use. Today, it is primarily utilized as an Аналитический эталонный стандарт for forensic toxicology, pharmacology, medicinal chemistry, and analytical laboratory research.

Due to its structural similarity to алпразолам, Bromazolam is widely studied for receptor-binding characteristics, metabolic profiling, and analytical method development.

What is Bromazolam?

Bromazolam is a laboratory-produced triazolobenzodiazepine developed for scientific investigation of benzodiazepine receptor pharmacology. It shares close structural similarities with alprazolam while containing a bromine substitution that makes it valuable for analytical differentiation and forensic identification.

Researchers utilize Bromazolam as a certified reference material when studying emerging benzodiazepine analogues, metabolic pathways, and analytical detection techniques.

Химическая структура и свойства

Bromazolam possesses several defining structural characteristics:

• Triazolobenzodiazepine core
• Бромированное ароматическое кольцо
• High chemical purity
• Stable crystalline structure
• Подходящий аналитический справочный материал

These characteristics make Bromazolam an important compound for benzodiazepine research and laboratory analysis.

Фармакологические исследования

Laboratory studies indicate Bromazolam functions as a positive allosteric modulator of the GABAA receptor, interacting with the benzodiazepine binding site.

Scientific investigations have demonstrated high affinity toward multiple GABAA receptor subtypes, making Bromazolam useful for:

• Исследования связывания рецепторов
• Pharmacodynamic research
• Neuropharmacology investigations
• Анализ взаимосвязи структуры и активности (SAR)
• Сравнительные исследования бензодиазепинов

Its receptor profile provides valuable information for medicinal chemistry and neuroscience research.

Metabolism Research

Bromazolam has been extensively investigated in human liver microsome and hepatocyte studies.

Major metabolic pathways include:

• Hydroxylation
• Dihydroxylation
• Glucuronidation
• Phase I metabolism
• Phase II metabolism

Reported metabolites include:

• Phenyl-hydroxy Bromazolam
• 4-Hydroxy Bromazolam
• Alpha-hydroxy Bromazolam
• Alpha-4-dihydroxy Bromazolam
• Bromazolam N-glucuronide
• Hydroxy Bromazolam glucuronides

These metabolites assist forensic laboratories in biological sample identification and toxicological investigations.

Приложения для научных исследований

Bromazolam is commonly used in:

• судебная токсикология
• медицинская химия
• Фармацевтические исследования
• Нейрофармакология
• аналитическая химия
• GABAA receptor research
• Эталонное стандартное производство
• Исследования метаболизма лекарственных средств
• Structure–Activity Relationship (SAR) research

Аналитические приложения

Professional laboratories utilize Bromazolam for:

• LC-MS/MS-анализ
• Идентификация GC-MS
• HPLC Analysis
• Масс-спектрометрия высокого разрешения (HRMS)
• Токсикологический скрининг
• Reference Standard Calibration
• Валидация метода
• Quality Control Testing

These analytical methods enable accurate detection and identification of Bromazolam in research environments.

Why Researchers Study Bromazolam

Bromazolam supports numerous laboratory investigations involving:

• Benzodiazepine analogue identification
• Оптимизация лекарственной химии
• Pharmaceutical compound development
• Forensic casework
• Проверка аналитического метода
• Metabolic pathway characterization
• Receptor pharmacology
• Обеспечение качества лаборатории

Its well-characterized structure makes it valuable for comparative studies involving triazolobenzodiazepines.

Связанные с исследованием Соединения

Researchers frequently compare Bromazolam with:

• Алпразолам
• Клоназолам
• Флубромазолам
• Флуалпразолам
• Этизолам
• Диазепам
• Midazolam
• Триазолам
• Other benzodiazepine analogues

Comparative investigations help improve analytical differentiation and pharmacological characterization.

Хранение и погрузочно-разгрузочные работы

Для оптимальной лабораторной стабильности:

• Хранить в герметичных лабораторных контейнерах.
• Keep away from moisture and humidity.
• Avoid prolonged light exposure.
• Поддерживайте рекомендуемую температуру хранения в лаборатории.
• Обращайтесь с ними, используя соответствующие лабораторные СИЗ.
• Предназначено только для квалифицированного лабораторного персонала.

Вопросы и ответы

What is Bromazolam?

Bromazolam is a triazolobenzodiazepine research chemical used as an analytical reference standard in forensic toxicology, medicinal chemistry, pharmacology, and analytical laboratories.

Which research fields use Bromazolam?

Bromazolam is widely used in forensic toxicology, pharmaceutical research, neuropharmacology, medicinal chemistry, analytical chemistry, and academic laboratory research.

Which analytical techniques are used with Bromazolam?

Researchers commonly analyze Bromazolam using LC-MS/MS, GC-MS, HPLC, and HRMS for compound identification, calibration, quality assurance, and method validation.

Why is Bromazolam valuable for research?

Its well-characterized receptor affinity, metabolic profile, and structural similarity to alprazolam make it valuable for analytical chemistry, forensic investigations, and medicinal chemistry research.

Is Bromazolam intended only for laboratory research?

Yes. Bromazolam is supplied exclusively for laboratory, scientific, analytical, forensic, and educational research purposes.

Отказ от ответственности

Bromazolam (XLI-268) предназначено Исключительно для лабораторных, аналитических, научных и образовательных исследований. , йо- Этот продукт не предназначен для употребления в пищу человеком, медицинского лечения, ветеринарного применения, терапевтических или диагностических целей. , йо- Пользователи несут ответственность за соблюдение всех действующих законов, правил и требований институциональных лабораторных требований по безопасности.